Leprosy: Treatment and management of complications

J Am Acad Dermatol. 2020 Jul;83(1):17-30. doi: 10.1016/j.jaad.2019.10.138. Epub 2020 Mar 31.

Abstract

In the second article in this continuing medical education series, we review the treatment of leprosy, its immunologic reactions, and important concepts, including disease relapse and drug resistance. A fundamental understanding of the treatment options and management of neuropathic sequelae are essential to reduce disease burden and improve patients' quality of life.

Keywords: Hansen's disease; Lucio phenomenon; National Hansen's Disease Program; chemoprophylaxis; disease burden; disease relapse; drug resistance; immunoprophylaxis; leprosy; leprosy treatment; prevention; type 1 leprosy reaction; type 2 leprosy reaction.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Cost of Illness
  • Drug Resistance, Bacterial
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leprosy / complications*
  • Leprosy / drug therapy*
  • Leprosy / immunology
  • Leprosy / pathology
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Quality of Life
  • Recurrence

Substances

  • Anti-Bacterial Agents