The Japanese Breast Cancer Society Clinical Practice Guidelines for systemic treatment of breast cancer, 2018 edition

Tatsunori Shimoi; Shigenori E Nagai; Tetsuhiro Yoshinami; Masato Takahashi; Hitoshi Arioka; Mikiya Ishihara; Yuichiro Kikawa; Kei Koizumi; Naoto Kondo; Yasuaki Sagara; Masahiro Takada; Toshimi Takano; Junji Tsurutani; Yoichi Naito; Rikiya Nakamura; Masaya Hattori; Fimikata Hara; Naoki Hayashi; Toshiro Mizuno; Minoru Miyashita; Nami Yamashita; Takashi Yamanaka; Shigehira Saji; Hiroji Iwata; Tatsuya Toyama

doi:10.1007/s12282-020-01085-0

The Japanese Breast Cancer Society Clinical Practice Guidelines for systemic treatment of breast cancer, 2018 edition

Breast Cancer. 2020 May;27(3):322-331. doi: 10.1007/s12282-020-01085-0. Epub 2020 Apr 2.

Authors

Tatsunori Shimoi^{1

2}, Shigenori E Nagai^{3

2}, Tetsuhiro Yoshinami^{4

2}, Masato Takahashi^{5

2}, Hitoshi Arioka^{6

2}, Mikiya Ishihara^{7

2}, Yuichiro Kikawa^{8

2}, Kei Koizumi^{9

2}, Naoto Kondo^{10

2}, Yasuaki Sagara^{11

2}, Masahiro Takada^{12

2}, Toshimi Takano^{13

2}, Junji Tsurutani^{14

2}, Yoichi Naito^{15

2}, Rikiya Nakamura^{16

2}, Masaya Hattori^{17

2}, Fimikata Hara^{18

2}, Naoki Hayashi^{19

2}, Toshiro Mizuno^{7

2}, Minoru Miyashita^{20

2}, Nami Yamashita^{21

2}, Takashi Yamanaka^{22

2}, Shigehira Saji^{23

2}, Hiroji Iwata^{17

2}, Tatsuya Toyama^{24

25}

Affiliations

¹ Department of Breast and Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji,, Chuo-ku, Tokyo, 104-0045, Japan.
² The Japanese Breast Cancer Society Clinical Practice Guidelines for Systemic Treatment of Breast Cancer Panel Membership, Tokyo, Japan.
³ Department of Breast Oncology, Saitama Cancer Center, 780 Komuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan.
⁴ Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, 2-2-E 10 Yamadaoka, Suita, Osaka, 565-0871, Japan.
⁵ Department of Breast Surgery, NHO Hokkaido Cancer Center, 4-2 Kikusui, Shiroishi-ku, Sapporo, 003-0804, Japan.
⁶ Department of Medical Oncology, Yokohama Rosai Hospital, 3211 Kozukue, Kohoku-ku, Yokohama, Kanagawa, 222-0036, Japan.
⁷ Department of Medical Oncology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
⁸ Department of Breast Surgery, Kobe City Medical Center General Hospital, 2-1-1, Minatojimaminamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
⁹ First Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka, 431-3192, Japan.
¹⁰ Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
¹¹ Department of Breast Surgical Oncology, Hakuaikai Social Cooperation, Sagara Hospital, 3-31 Matsubara-cho, Kagoshima, 892-0098, Japan.
¹² Department of Breast Surgery, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
¹³ Department of Medical Oncology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.
¹⁴ Department of Medical Oncology, Advanced Cancer Translational Research Institute, Showa University, 1-5-8 Hatanodai, Shinagawa, Tokyo, Japan.
¹⁵ Department of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
¹⁶ Department of Breast Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, Chiba, 280-8717, Japan.
¹⁷ Department of Breast Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
¹⁸ Department of Breast Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
¹⁹ Department of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.
²⁰ Department of Breast and Endocrine Surgical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
²¹ Department of Surgery and Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
²² Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Ashahi-ku, Yokohama, 241-8515, Japan.
²³ Department of Medical Oncology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
²⁴ Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. t.toyama@med.nagoya-cu.ac.jp.
²⁵ The Japanese Breast Cancer Society Clinical Practice Guidelines for Systemic Treatment of Breast Cancer Panel Membership, Tokyo, Japan. t.toyama@med.nagoya-cu.ac.jp.

Abstract

Purpose: We present the English version of The Japanese Breast Cancer Society (JBCS) Clinical Practice Guidelines for systemic treatment of breast cancer, 2018 edition.

Methods: The JBCS formed a task force to update the JBCS Clinical Practice Guidelines, 2015 edition, according to Minds Handbook for Clinical Practice Guideline Development 2014. First, we set multiple outcomes for each clinical question (CQ). Next, quantitative or qualitative systematic review was conducted for each of the multiple outcomes, and the strength of recommendation for the CQ was taken into consideration during meetings, with the aim of finding a balance between benefit and harm. Finalized recommendations from each session were confirmed through discussion and voting at the recommendation decision meeting.

Results: The recommendations, the strength of recommendation and the strength of evidence were determined based on systemic literature reviews and the meta-analyses for each CQ.

Conclusion: The JBCS updated the Clinical Practice Guidelines for systemic treatment of breast cancer.

Keywords: Breast cancer; Guideline; Systemic treatment.

MeSH terms

Breast Neoplasms / pathology
Breast Neoplasms / therapy*
Combined Modality Therapy
Female
Humans
Japan
Medical Oncology
Practice Guidelines as Topic / standards*
Prognosis