Expression and role of ERAP1 in placental tissues of preeclampsia

Hypertens Pregnancy. 2020 May;39(2):165-171. doi: 10.1080/10641955.2020.1749848. Epub 2020 Apr 2.

Abstract

Objective: This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis.Methods: ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen).Results: The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia.Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.

Keywords: ERAP1; Preeclampsia; pathogenesi.

MeSH terms

  • Adult
  • Aminopeptidases / genetics
  • Aminopeptidases / metabolism*
  • Cell Line
  • Female
  • Humans
  • Minor Histocompatibility Antigens / genetics
  • Minor Histocompatibility Antigens / metabolism*
  • Placenta / metabolism*
  • Pre-Eclampsia / genetics
  • Pre-Eclampsia / metabolism*
  • Pregnancy
  • Trophoblasts / metabolism

Substances

  • Minor Histocompatibility Antigens
  • Aminopeptidases
  • ERAP1 protein, human