Abstract
N-Truncated Aβ4-42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aβ4-42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ4-42 during neurotransmission.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / metabolism*
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Amyloid beta-Peptides / chemistry
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Amyloid beta-Peptides / metabolism*
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Copper / chemistry
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Copper / metabolism*
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Kinetics
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Models, Chemical
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Molecular Structure
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Peptide Fragments / chemistry
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Peptide Fragments / metabolism*
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Protein Binding
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Thermodynamics
Substances
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Amyloid beta-Peptides
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Peptide Fragments
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Copper