Hierarchical binding of copperII to N-truncated Aβ4-16 peptide

Metallomics. 2020 Apr 1;12(4):470-473. doi: 10.1039/c9mt00299e. Epub 2020 Apr 1.

Abstract

N-Truncated Aβ4-42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aβ4-42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ4-42 during neurotransmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / metabolism*
  • Copper / chemistry
  • Copper / metabolism*
  • Kinetics
  • Models, Chemical
  • Molecular Structure
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism*
  • Protein Binding
  • Thermodynamics

Substances

  • Amyloid beta-Peptides
  • Peptide Fragments
  • Copper