Controversies around the function of LARP1

RNA Biol. 2021 Feb;18(2):207-217. doi: 10.1080/15476286.2020.1733787. Epub 2020 Apr 1.

Abstract

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.

Keywords: LARP; LARP1; La-related protein 1; PABP; cancer; mRNA; mTOR; mTORC1; poly A binding protein; translation.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantigens / chemistry
  • Autoantigens / genetics
  • Autoantigens / metabolism*
  • Binding Sites
  • Carrier Proteins
  • Gene Expression Regulation
  • Humans
  • Multigene Family
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • RNA / chemistry
  • RNA / metabolism
  • RNA Cleavage
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Ribonucleoproteins / chemistry
  • Ribonucleoproteins / genetics
  • Ribonucleoproteins / metabolism*
  • SS-B Antigen
  • Signal Transduction
  • Substrate Specificity

Substances

  • Autoantigens
  • Carrier Proteins
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • RNA