Prevalence and type distribution of human papillomavirus in a Chinese urban population between 2014 and 2018: a retrospective study

Mei-Yan Xu; Bing Cao; Yan Chen; Juan Du; Jian Yin; Lan Liu; Qing-Bin Lu

doi:10.7717/peerj.8709

Prevalence and type distribution of human papillomavirus in a Chinese urban population between 2014 and 2018: a retrospective study

PeerJ. 2020 Mar 23:8:e8709. doi: 10.7717/peerj.8709. eCollection 2020.

Authors

Mei-Yan Xu^#¹, Bing Cao^#², Yan Chen³, Juan Du⁴, Jian Yin¹, Lan Liu⁵, Qing-Bin Lu^{4

6}

Affiliations

¹ Department of Nutrition, Aerospace Center Hospital, Beijing, China.
² Key Laboratory of Cognition and Personality (SWU), Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, China.
³ Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
⁴ Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
⁵ Department of Health Management, Aerospace Center Hospital, Beijing, China.
⁶ Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, China.

^# Contributed equally.

Abstract

Background: Human papilloma virus (HPV) infection is one of the most common sexually transmitted infections among women worldwide. The current study's main objective is to report the prevalence and distribution of HPV types in an urban population in Beijing, China.

Methods: All the eligible female participants aged ≥18 years were recruited from the Aerospace Center Hospital in Beijing, China between 2014 and 2018. A total of 21 HPV types were detected by the polymerase chain reaction (PCR) reverse dot blot method and fluorescence quantitative PCR method.

Results: In total, 12 high risk HPV types and nine low risk HPV types were detected. The HPV-positive rates were 8.85% in 2014, 7.16% in 2015, 7.60% in 2016, 8.31% in 2017, and 7.72% in 2018, respectively, in an urban population in Beijing, China. Overall, no significant differences in the HPV-positive rates were found over the five years. The peak prevalence of HPV infection in all types was observed in age group of 20-24 in all types. HPV52 was the dominant HPV type across the five years . Among all 21 HPV types, HPV66, HPV26, and HPV59 were ranked the top three in coinfection occurrence.

Conclusions: Our findings are very helpful for HPV screening and vaccination. The associations between gynaecological diseases and the HPV types with high prevalence, particularly HPV52, warrant further investigation.

Keywords: China; Genotype; Human Papillomavirus; Infection; Prevalence; Screening; Urban.

Grants and funding

The study was supported by National Natural Science Foundation of China (No. 81703274), the China Mega-Project for Infectious Diseases Grant (2017ZX10103004), the Youth Innovation Funding (2014QN09) and the Peking University Medicine Seed Fund for Interdisciplinary Research (BMU2018MX009). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.