The Apelin/APJ System in Psychosis and Neuropathy

Shuang-Yu Lv; Wei-Dong Chen; Yan-Dong Wang

doi:10.3389/fphar.2020.00320

The Apelin/APJ System in Psychosis and Neuropathy

Front Pharmacol. 2020 Mar 13:11:320. doi: 10.3389/fphar.2020.00320. eCollection 2020.

Authors

Shuang-Yu Lv¹, Wei-Dong Chen^{1

2}, Yan-Dong Wang³

Affiliations

¹ Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Medicine, Henan University, Kaifeng, China.
² Key Laboratory of Molecular Pathology, School of Basic Medical Science, Inner Mongolia Medical University, Hohhot, China.
³ State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.

Abstract

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy.

Keywords: apelin; brain injury; memory; neuroprotection; pain.

Publication types

Review