Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay

Yasin Orooji; Mahsa Haddad Irani-Nezhad; Ramin Hassandoost; Alireza Khataee; Shima Rahim Pouran; Sang Woo Joo

doi:10.1016/j.saa.2020.118272

Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay

Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jun 15:234:118272. doi: 10.1016/j.saa.2020.118272. Epub 2020 Mar 17.

Authors

Yasin Orooji¹, Mahsa Haddad Irani-Nezhad², Ramin Hassandoost², Alireza Khataee³, Shima Rahim Pouran⁴, Sang Woo Joo⁵

Affiliations

¹ College of Materials Science and Engineering, Nanjing Forestry University, No. 159, Longpan Road, Nanjing, 210037, Jiangsu, People's Republic of China; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
² Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
³ Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran; Department of Environmental Engineering, Gebze Technical University, 41400 Gebze, Turkey; Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address: alirezakhataee@duytan.edu.vn.
⁴ Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran.
⁵ School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea. Electronic address: swjoo@yu.ac.kr.

PMID: 32229321
DOI: 10.1016/j.saa.2020.118272

Abstract

Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-K₃Fe(CN)₆ chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10^-6-9.37 × 10^-5 mol/L was obtained with a limit of detection of 3.91 × 10^-7 mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.

Keywords: Antibiotics detection; Chemiluminescence; Human plasma; Magnetic sensor; Metronidazole.

MeSH terms

Cerium / chemistry*
Humans
Kinetics
Luminescent Measurements / methods*
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / ultrastructure
Metronidazole / analysis*
Metronidazole / blood
Photoelectron Spectroscopy
Temperature

Substances

Magnetite Nanoparticles
Metronidazole
Cerium