Pediatric Community-Acquired Bone and Joint Staphylococcus Aureus Infections In Europe: Severe Infections are Associated to Panton-Valentine Leucocidin Presence

Pediatr Infect Dis J. 2020 Jun;39(6):e73-e76. doi: 10.1097/INF.0000000000002640.

Abstract

To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Arthritis, Infectious / epidemiology*
  • Arthritis, Infectious / microbiology
  • Bacterial Toxins / genetics*
  • Bone and Bones / microbiology
  • Child
  • Child, Preschool
  • Community-Acquired Infections / epidemiology*
  • Community-Acquired Infections / microbiology*
  • Europe / epidemiology
  • Exotoxins / genetics*
  • Humans
  • Infant
  • Infant, Newborn
  • Joints / microbiology
  • Leukocidins / genetics*
  • Methicillin-Resistant Staphylococcus aureus / pathogenicity
  • Prospective Studies
  • Severity of Illness Index
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / transmission
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / pathogenicity
  • Virulence Factors

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin
  • Virulence Factors