Antibiotic Resistance Profile and Methicillin-Resistant Encoding Genes of Staphylococcus aureus Strains Isolated from Bloodstream Infection Patients in Northern Vietnam

Le Van Nam; Do Quyet; Pham Ngoc Hung; Tran Viet Tien; Kieu Chi Thanh; Quan Anh Dung; Do Dieu Linh; Ha The Tan; Nguyen Duy Bac; Thien Chu Dinh; Dinh Cong Pho

doi:10.3889/oamjms.2019.871

Antibiotic Resistance Profile and Methicillin-Resistant Encoding Genes of Staphylococcus aureus Strains Isolated from Bloodstream Infection Patients in Northern Vietnam

Open Access Maced J Med Sci. 2019 Dec 20;7(24):4406-4410. doi: 10.3889/oamjms.2019.871. eCollection 2019 Dec 30.

Authors

Le Van Nam¹, Do Quyet², Pham Ngoc Hung^{3

4}, Tran Viet Tien¹, Kieu Chi Thanh⁵, Quan Anh Dung⁶, Do Dieu Linh⁷, Ha The Tan³, Nguyen Duy Bac⁴, Thien Chu Dinh⁸, Dinh Cong Pho⁶

Affiliations

¹ Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
² Director of Vietnam Military Medical University, Department of Tuberculosis and Lung Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
³ Department of Epidemiology, Vietnam Military Medical University, Hanoi, Vietnam.
⁴ Department of Training, Vietnam Military Medical University, Hanoi, Vietnam.
⁵ Department of Hospital Infection Control, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
⁶ Faculty of Medicine, Vietnam Military Medical University, Hanoi, Vietnam.
⁷ Faculty of Medicine, Hai Phong Medical University, 72A Nguyen Binh Khiem, Hai Phong, Vietnam.
⁸ Institute for Research and Development, Duy Tan University, 03 Quang Trung, Danang, Vietnam.

Abstract

Background: Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). Nevertheless, there are still limited studies in Northern Vietnam. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Aim: This study aimed to determine the antibiotic resistance profile and methicillin-resistant encoding genes of Staphylococcus aureus (S. aureus) causing BSIs in Northern Vietnam.

Methods: The cross-sectional study was done from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests performed at the lab of the hospital.

Results: In 43 S. aureus strains isolating, 53.5 % were MRSA. Distribution of gene for overall, MRSA, and MSSA strains were following mecA gene (58.1 %; 95.7%, and 15%), femA gene (48.8%, 47.8%, and 50%), femB gene (88.4%, 82.6%, and 95%). Antibiotic resistance was highest in penicillin (100%), followed by erythromycin (65.1%) and clindamycin (60.5%). Several antibiotics were susceptible (100%), including vancomycin, tigecycline, linezolid, quinupristin/dalfopristin. Quinolone group was highly sensitive, include ciprofloxacin (83.7%), levofloxacin (86%) and moxifloxacin (86%).

Conclusion: In S. aureus causing BSIs, antibiotic resistance was higher in penicillin, erythromycin, and clindamycin. All strains were utterly susceptible to vancomycin, tigecycline, linezolid, quinupristin/dalfopristin.

Keywords: Antibiotic resistance; MRSA (methicillin-resistant staphylococcus aureus); MRSA encoding genes; MSSA (methicillin-susceptible staphylococcus aureus); Staphylococcus aureus (S. aureus); bloodstream infections (BSIs).