Synthesis and Antiviral Activity of Several N-Containing 5 α-STEROIDS

N Sh Nadaraia; E O Onashvili; M L Kakhabrishvili; N N Barbakadze; B Sylla; A Pichette

doi:10.1007/s10600-016-1795-0

Synthesis and Antiviral Activity of Several N-Containing 5 α-STEROIDS

Chem Nat Compd. 2016;52(5):853-855. doi: 10.1007/s10600-016-1795-0. Epub 2016 Aug 11.

Authors

N Sh Nadaraia¹, E O Onashvili¹, M L Kakhabrishvili¹, N N Barbakadze¹, B Sylla², A Pichette²

Affiliations

¹ 1I. Kutateladze Institute of Pharmaceutical Chemistry, Tbilisi State Medical University, Tbilisi, 0159 Georgia.
² 2LASEVE, Universite Quebec a Chicoutim, Chicoutimi, QC Canada G7H 2BI.

Abstract

A study of the antiviral activity of several new hydrazones and amines and amides of 5α-steroids that were synthesized by us earlier found highly and moderately active compounds. The structures of the synthesized compounds were proven using IR, PMR, ¹³C NMR, and mass spectral data.

Keywords: 5α-steroids; amides; amines; antiviral activity; hydrazides; hydrazones; synthesis.