Abstract
Sporormielones A-E (1-5), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.
MeSH terms
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Alzheimer Disease
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Animals
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Ascomycota / metabolism
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Dimerization
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Diptera
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Gene Expression Profiling
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Memory, Short-Term / drug effects
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Neuroprotective Agents* / chemistry
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Neuroprotective Agents* / metabolism
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Neuroprotective Agents* / pharmacology
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Resorcinols* / chemistry
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Resorcinols* / metabolism
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Resorcinols* / pharmacology
Substances
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Neuroprotective Agents
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Resorcinols
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orsellinic acid