Serum level of long noncoding RNA B3GALT5-AS1 as a diagnostic biomarker of colorectal cancer

Future Oncol. 2020 May;16(13):827-835. doi: 10.2217/fon-2019-0820. Epub 2020 Mar 24.

Abstract

Aim: Long noncoding RNA (lncRNA) B3GALT5-AS1 has been reported as a biomarker for cancer monitoring. This research aims to identify serum long noncoding RNA B3GALT5-AS1 as a new biomarker for the diagnosis of colorectal cancer (CRC) and evaluate its clinical value. Materials & methods: Serum B3GALT5-AS1 expression levels were measured by quantitative real-time PCR. Results: The level of B3GALT5-AS1 in CRC patients was significantly lower than that of healthy patients (p < 0.0001). Further exploration validated that high serum B3GALT5-AS1 level was related to tumor node metastasis (TNM) stage (p = 0.008) and histological differentiation (p = 0.027). Compared with the healthy control group, AUCROC of serum B3GALT5-AS1 in the CRC group was 0.762 with 95% CI: 0.698-0.826 (p < 0.0001). Conclusion: B3GALT5-AS1 may be served as a diagnostic marker for distinguishing CRC patients from healthy people.

Keywords: biomarker; colorectal cancer; diagnosis; lncRNA B3GALT5-AS1; serum.

MeSH terms

  • Biomarkers, Tumor / blood*
  • Biomarkers, Tumor / genetics
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Colonic Neoplasms / blood*
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / genetics
  • Colorectal Neoplasms / blood*
  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / genetics
  • Female
  • Galactosyltransferases / blood*
  • Galactosyltransferases / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • RNA, Long Noncoding / blood*
  • RNA, Long Noncoding / genetics

Substances

  • Biomarkers, Tumor
  • RNA, Long Noncoding
  • B3GALT5 protein, human
  • Galactosyltransferases