Composite scaffolds based on calcium phosphates and barium titanate obtained through bacterial cellulose templated synthesis

Abstract

Taking into account the potential of barium titanate to deliver electrical stimulation to the physiological microenvironment and offer beneficial conditions for the cellular metabolism, this mineral phase was selected for the development of new composites. In this context, calcium phosphates and barium titanate were deposited on bacterial cellulose membranes under ultrasonic irradiation, the resulting system being subjected to a thermal treatment in optimized conditions in order to remove the polymeric template and achieve 3D porous architectures. The complex characterization performed on the intermediate and final samples demonstrated the suitability of such materials for hard tissue engineering applications.

Keywords: Bacterial cellulose; Barium titanate; Biocompatibility; Calcium phosphates; Composite scaffolds.