Abstract
Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase the risk for iatrogenic hypoglycemia.
Keywords:
Diabetes complications; Hypoglycemia; Ketosis.
Copyright © 2020 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Glucose / metabolism
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Cerebrum / metabolism
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Corticosterone / blood
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Corticosterone / metabolism
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Diet, Ketogenic / adverse effects*
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Disease Models, Animal
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Feedback, Physiological
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Glucagon / blood
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Glucagon / metabolism*
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Glucose / analysis
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Glucose / metabolism*
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Hypoglycemia / blood
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Hypoglycemia / etiology
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Hypoglycemia / metabolism*
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Hypoglycemia / physiopathology
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Male
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Mice
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Mice, Inbred C57BL
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Risk Factors
Substances
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Blood Glucose
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Glucagon
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Glucose
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Corticosterone