Consuming a ketogenic diet leads to altered hypoglycemic counter-regulation in mice

J Diabetes Complications. 2020 May;34(5):107557. doi: 10.1016/j.jdiacomp.2020.107557. Epub 2020 Feb 8.

Abstract

Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase the risk for iatrogenic hypoglycemia.

Keywords: Diabetes complications; Hypoglycemia; Ketosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Cerebrum / metabolism
  • Corticosterone / blood
  • Corticosterone / metabolism
  • Diet, Ketogenic / adverse effects*
  • Disease Models, Animal
  • Feedback, Physiological
  • Glucagon / blood
  • Glucagon / metabolism*
  • Glucose / analysis
  • Glucose / metabolism*
  • Hypoglycemia / blood
  • Hypoglycemia / etiology
  • Hypoglycemia / metabolism*
  • Hypoglycemia / physiopathology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Risk Factors

Substances

  • Blood Glucose
  • Glucagon
  • Glucose
  • Corticosterone