Penile pacinian neurofibroma

Abstract

Pacinian neurofibroma (PNF) is a lobulated benign neural tumor with prominent structures resembling pacinian bodies. These tumors most commonly occur in areas where normal pacinian bodies are found, such as the hands and feet. Although pacinian bodies are common in the penis, no cases of penile PNF have been reported to date. We present a case of PNF on the dorsal glans penis of a 47-year-old man. The lesion presented as a single flesh-colored papule and the biopsy showed a dermal neurofibroma consisting of bland spindle cells with wavy nuclei, without mitoses or atypia, and some nodular structures with a concentric arrangement and a pacinian appearance. Immunohistochemistry demonstrated positivity for CD34 and Vimetin and negativity for Epithelial Membrane Antigen (EMA). S100 was highly positive in the most central areas of the pacinian-like nodules, while the periphery and non-nodular parts of the neurofibroma were less intensively expressed.

Keywords: Corpúsculo paciniano; Fibroma de células perineurales pacinianas; Fibrous perineurioma; Neurofibroma paciniano; Pacinian corpuscule; Pacinian neurofibroma; Pacinian perineural cell fibroma; Perineurioma esclerosante; Perineurioma fibroso; Sclerosing perineurioma.