Comparative assessment of periodontal regeneration in periodontal intraosseous defects treated with PepGen P-15 unaided or in blend with platelet-rich fibrin: A clinical and high-resolution computed tomography scan-assisted volumetric analysis

Jyotsna Goyal; Surinder Sachdeva; Sanjeev Kumar Salaria; Nishu Vakil; Amit Mittal

doi:10.4103/jisp.jisp_351_19

Comparative assessment of periodontal regeneration in periodontal intraosseous defects treated with PepGen P-15 unaided or in blend with platelet-rich fibrin: A clinical and high-resolution computed tomography scan-assisted volumetric analysis

J Indian Soc Periodontol. 2020 Mar-Apr;24(2):156-162. doi: 10.4103/jisp.jisp_351_19. Epub 2020 Mar 2.

Authors

Jyotsna Goyal¹, Surinder Sachdeva², Sanjeev Kumar Salaria³, Nishu Vakil⁴, Amit Mittal⁵

Affiliations

¹ Department of Periodontology, Luxmi Bai Institute of Dental Sciences and Hospital, Patiala, Punjab, India.
² Department of Periodontology, Maharishi Markandeshwar College of Dental Sciences and Research, Maharishi Markandeshwar University, Mullana, Haryana, India.
³ Department of Periodontology and Implantology, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India.
⁴ Department of Periodontology, Indira Gandhi Government Dental College, Jammu, Jammu and Kashmir, India.
⁵ Department of Radiodiagnosis, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar University, Mullana, Haryana, India.

Abstract

Background: PepGen P-15, a xenograft, has proven its periodontal regenerative potential. Platelet-rich fibrin (PRF) is an autologous platelet concentrate which too contributes to periodontal redevelopment through the release of different polypeptide progression factors. The present study intended to evaluate the regenerative potential of PepGen P-15 xenograft when used unaccompanied or in blend with PRF in periodontal intraosseous defects in humans through clinical and a novel computed tomography (CT) scan analysis technique.

Materials and methods: Twelve chronic periodontitis individuals with paired periodontal intraosseous defects were randomly treated either with PepGen P-15 exclusively (Control/Group A) or in concoction with PRF (Test/Group B) utilizing split-mouth study design. Pocket probing depth (PPD), relative attachment level (RAL), and relative position of gingival margin were assessed at 3- and 6-month interval, whereas the linear and volumetric bone defect regeneration were assessed at 6 months postoperatively using CT scan.

Results: Both the groups validated statistically significant PPD reduction, RAL gain at 3 and 6 months, but on intergroup comparison, test group CT images revealed significantly greater linear bone gain and volumetric bone gain, with mean difference of 0.73 ± 0.28 (P = 0.018) and 2.70 ± 1.36 (P = 0.06) at 6 months in comparison to the baseline data.

Conclusions: PepGen P-15 and PRF blend had better regeneration potential for the management of intrabony defects. Further long-term investigations on large sample size are recommended to authenticate the same.

Keywords: Computed tomography scan; PepGen P-15; intrabony defects; periodontal regeneration; platelet-rich fibrin.