Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update

Geraldine M Ahmed; Eman A Abouauf; Nermeen AbuBakr; Christof E Dörfer; Karim Fawzy El-Sayed

doi:10.1155/2020/5734539

Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update

Stem Cells Int. 2020 Feb 25:2020:5734539. doi: 10.1155/2020/5734539. eCollection 2020.

Authors

Geraldine M Ahmed^{1

2}, Eman A Abouauf^{1

3}, Nermeen AbuBakr^{1

4}, Christof E Dörfer⁵, Karim Fawzy El-Sayed^{1

5

6}

Affiliations

¹ Stem Cell and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.
² Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.
³ Department of Conservative Dentistry, Faculty of Dentistry, Cairo University, Cairo, Egypt.
⁴ Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
⁵ Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.
⁶ Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Abstract

Stem/progenitor cells are undifferentiated cells characterized by their exclusive ability for self-renewal and multilineage differentiation potential. In recent years, researchers and investigations explored the prospect of employing stem/progenitor cell therapy in regenerative medicine, especially stem/progenitor cells originating from the oral tissues. In this context, the regeneration of the lost dental tissues including enamel, dentin, and the dental pulp are pivotal targets for stem/progenitor cell therapy. The present review elaborates on the different sources of stem/progenitor cells and their potential clinical applications to regenerate enamel, dentin, and the dental pulpal tissues.

Publication types

Review