Inhibition of the ketolytic acetyl CoA supply to tumors could be their "Achilles heel"

Int J Cancer. 2020 Sep 15;147(6):1755-1757. doi: 10.1002/ijc.32979. Epub 2020 Mar 31.
No abstract available

Publication types

  • Letter

MeSH terms

  • Acetyl Coenzyme A / metabolism*
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Coenzyme A-Transferases / antagonists & inhibitors*
  • Coenzyme A-Transferases / metabolism
  • Combined Modality Therapy / methods
  • Diet, Ketogenic*
  • Humans
  • Liver / cytology
  • Liver / metabolism
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Warburg Effect, Oncologic / drug effects

Substances

  • Antineoplastic Agents
  • Acetyl Coenzyme A
  • Coenzyme A-Transferases
  • 3-ketoacid CoA-transferase