Targeting with nanoparticles for the therapeutic treatment of brain diseases

Guang-Zhen Jin; Atanu Chakraborty; Jung-Hwan Lee; Jonathan C Knowles; Hae-Won Kim

doi:10.1177/2041731419897460

Targeting with nanoparticles for the therapeutic treatment of brain diseases

J Tissue Eng. 2020 Mar 4:11:2041731419897460. doi: 10.1177/2041731419897460. eCollection 2020 Jan-Dec.

Authors

Guang-Zhen Jin^{1

2

3}, Atanu Chakraborty¹, Jung-Hwan Lee^{1

2

3

4}, Jonathan C Knowles^{1

4

5}, Hae-Won Kim^{1

2

3

4}

Affiliations

¹ Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea.
² Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Republic of Korea.
³ Department of Nanobiomedical Science and BK21 PLUS Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.
⁴ UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea.
⁵ Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, UK.

Abstract

Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost. Nanoparticles that load and deliver drugs and genes have been intensively studied for the treatment of brain diseases, and have demonstrated some biological effects in various animal models. Among other efforts taken in the nanoparticle development, targeting of blood brain barrier, specific cell type or local intra-/extra-cellular space is an important strategy to enhance the therapeutic efficacy of the nanoparticle delivery systems. This review underlies the targeting issue in the nanoparticle development for the treatment of brain diseases, taking key exemplar studies carried out in various in vivo models.

Keywords: Brain diseases; blood brain barrier; in vivo models; nanoparticles; targeting.

Publication types

Review