The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions

Curr Pharm Des. 2020;26(21):2475-2491. doi: 10.2174/1381612826666200316145725.

Abstract

Vitamin D is a steroid hormone implicated in the regulation of neuronal integrity and many brain functions. Its influence, as a nutrient and a hormone, on the physiopathology of the most common neurodegenerative diseases is continuously emphasized by new studies. This review addresses what is currently known about the action of vitamin D on the nervous system and neurodegenerative diseases such as Multiple Sclerosis, Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. Further vitamin D research is necessary to understand how the action of this "neuroactive" steroid can help to optimize the prevention and treatment of several neurological diseases.

Keywords: Alzheimer's disease; Parkinson's disease; Vitamin D; amyotrophic lateral sclerosis; multiple sclerosis; neurodegenerative diseases..

Publication types

  • Review

MeSH terms

  • Alzheimer Disease*
  • Humans
  • Multiple Sclerosis*
  • Vitamin D
  • Vitamins

Substances

  • Vitamins
  • Vitamin D