The Crosstalk Between Hippo-YAP Pathway and Innate Immunity

Front Immunol. 2020 Feb 27:11:323. doi: 10.3389/fimmu.2020.00323. eCollection 2020.

Abstract

Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. Hippo-YAP pathway regulates cell proliferation, survival, differentiation and is involved in diverse life processes, including tissue homeostasis and tumor suppression. Emerging discoveries elucidated that the components of Hippo-YAP pathway, such as MST1/2, NDR1/2, and YAP/TAZ played crucial regulatory roles in innate immunity. Meanwhile the innate immune signaling also exhibited regulatory effect on Hippo-YAP pathway. As for the importance of these two pathways, it would be interesting to figure out the deeper biological implications of their interplays. This review focuses on the regulation between Hippo-YAP pathway and innate immune signaling. We also propose the possible contribution of these interplays to tumor development.

Keywords: Hippo-YAP pathway; NF-kB signaling; innate immunity; tumor development; type I interferon.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology*
  • Animals
  • Hippo Signaling Pathway
  • Humans
  • Immunity, Innate / physiology*
  • Inflammation / etiology
  • Interferon Type I / physiology
  • NF-kappa B / physiology
  • Neoplasms / etiology
  • Protein Serine-Threonine Kinases / physiology*
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / physiology
  • Transcription Factors / physiology*
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Interferon Type I
  • NF-kappa B
  • Reactive Oxygen Species
  • Transcription Factors
  • YAP-Signaling Proteins
  • YAP1 protein, human
  • MAP4K3 protein, human
  • Protein Serine-Threonine Kinases
  • STK38 protein, human