On age-dependent bone remodeling

Areti Papastavrou; Ina Schmidt; Kefu Deng; Paul Steinmann

doi:10.1016/j.jbiomech.2020.109701

On age-dependent bone remodeling

J Biomech. 2020 Apr 16:103:109701. doi: 10.1016/j.jbiomech.2020.109701. Epub 2020 Feb 26.

Authors

Areti Papastavrou¹, Ina Schmidt², Kefu Deng³, Paul Steinmann³

Affiliations

¹ Faculty of Mechanical Engineering, Nuremberg Tech, Keßlerplatz 12, 90489 Nuremberg, Germany. Electronic address: areti.papastavrou@th-nuernberg.de.
² Faculty of Mechanical Engineering, Nuremberg Tech, Keßlerplatz 12, 90489 Nuremberg, Germany.
³ Chair of Applied Mechanics, University of Erlangen-Nuremberg, Egerlandstraße 5, 91058 Erlangen, Germany.

PMID: 32169286
DOI: 10.1016/j.jbiomech.2020.109701

Abstract

A number of previous studies have investigated the possibilities of modelling the change in density of bones. Remodeling can be formulated at the constitutive or the kinematic level. In this work we introduce a formulation for the density growth process which takes not only the mechanical stimulus into account but also the influence of age on the evolution of growth. We demonstrate the implementation in the context of the finite element method. This novel approach is illustrated for a simple uniaxial extension test and is verified against previous numerical results. Moreover, two further physiologically motivated examples are performed. The results of the proposed modified model show excellent agreement with comparable results from literature and are promising for the application to real-life problems.

Keywords: Adaption; Bone remodeling; Density change; Finite element method; Growth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Biomechanical Phenomena
Bone Density / physiology*
Bone Remodeling / physiology*
Computer Simulation*
Humans
Models, Biological*
Stress, Mechanical