Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism

Horm Metab Res. 2020 Jun;52(6):379-385. doi: 10.1055/a-1120-8647. Epub 2020 Mar 13.

Abstract

Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of AT1R-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on AT1R-Abs in PA.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Neoplasms / complications
  • Adrenal Cortex Neoplasms / immunology
  • Adrenal Cortex Neoplasms / metabolism
  • Adrenocortical Adenoma / complications
  • Adrenocortical Adenoma / immunology
  • Adrenocortical Adenoma / metabolism
  • Aldosterone / metabolism
  • Angiotensin II Type 1 Receptor Blockers / metabolism
  • Autoantibodies / metabolism
  • Autoantibodies / physiology*
  • Female
  • Humans
  • Hyperaldosteronism / etiology*
  • Hyperaldosteronism / immunology*
  • Hypertension / etiology
  • Hypertension / metabolism
  • Male
  • Pre-Eclampsia / etiology
  • Pre-Eclampsia / metabolism
  • Pregnancy
  • Receptor, Angiotensin, Type 1 / immunology*

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Autoantibodies
  • Receptor, Angiotensin, Type 1
  • Aldosterone