Abstract
Provision of infection security in transplantology and transfusiology is a challenging and significant problem that depends on the quality of medical donor selection and laboratory diagnosis of the blood collected. At present, a large number of blood-borne viruses are known; nevertheless, in Russia, the list of viral agents to be tested during the examination by the blood service boils down to three ones: HIV, hepatitis C and hepatitis B viruses. The review article demonstrates the need for implementation of additional laboratory tests for the agents of the priority healthcare-associated blood-borne infections (HAI) using a risk-based approach, i.e., on specified sites and in high risk groups. It presents a methodology for determination of a quantitative blood-induced infection residual risk (BIRR) index to be used while evaluating the efficiency of viral security provision in the blood service.
Keywords:
blood-borne nosocomial viral infections; hemotransfusion; residual risk of a blood-induced infection.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Blood Transfusion
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Deltaretrovirus Infections / diagnosis
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Deltaretrovirus Infections / epidemiology
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Deltaretrovirus Infections / prevention & control*
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Deltaretrovirus Infections / virology
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Disease Transmission, Infectious / prevention & control*
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Disease Transmission, Infectious / statistics & numerical data
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HIV Infections / diagnosis
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HIV Infections / epidemiology
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HIV Infections / prevention & control*
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HIV Infections / virology
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HIV-1 / pathogenicity
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HIV-1 / physiology
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HIV-2 / pathogenicity
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HIV-2 / physiology
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Hepacivirus / pathogenicity
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Hepacivirus / physiology
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Hepatitis B virus / pathogenicity
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Hepatitis B virus / physiology
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Hepatitis, Viral, Human / diagnosis
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Hepatitis, Viral, Human / epidemiology
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Hepatitis, Viral, Human / prevention & control*
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Hepatitis, Viral, Human / virology
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Herpes Simplex / diagnosis
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Herpes Simplex / epidemiology
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Herpes Simplex / prevention & control*
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Herpes Simplex / virology
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Human T-lymphotropic virus 1 / pathogenicity
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Human T-lymphotropic virus 1 / physiology
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Human T-lymphotropic virus 2 / pathogenicity
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Human T-lymphotropic virus 2 / physiology
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Humans
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Russia / epidemiology
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Simplexvirus / pathogenicity
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Simplexvirus / physiology
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Tissue Transplantation