Single application of lamellar moisturizers provides significantly increased hydration of the stratum corneum for up to 24 hours in a randomized trial

Abstract

Background: Some moisturizing formulations can help restore and maintain the barrier function of the skin.

Objectives: This study was designed to assess the hydration potential of three lamellar moisturizers relative to a control (nonlamellar) moisturizer.

Methods: Healthy adults aged 18 to 65 years with self-reported sensitive skin, dry or very dry skin and Corneometry values of ≤40 a.u. on the lower legs, entered this randomized, evaluator-blind study. Products A and B together with a control product (Control X) were applied to one leg, while Product C and Control Y were applied to the other leg; with an untreated control site in both cases. The primary efficacy variable was the change from baseline in Corneometer assessments at 24 hours (Products A and B) or 12 hours (Product C) postapplication.

Results: At all timepoints (n = 30), Products A and B showed higher mean Corneometer readings compared to baseline and changes from baseline were statistically significant when compared to untreated sites. Higher mean readings relative to baseline were seen at sites treated with Control X (smaller magnitude than Product A and B) and with Product C. These changes were significant compared to the untreated site at 30 minutes and 2 hours (Control X), and at 30 minutes and 12 hours (Product C). Additionally, Control Y increased significantly at 12 hours.

Conclusion: A single application of a lamellar moisturizer significantly increased hydration of the stratum corneum for up to 24 hours (Products A and B) or 12 hours (Product C).

Keywords: moisturizing; skin barrier.