Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer

Nanomedicine (Lond). 2020 Apr;15(9):833-849. doi: 10.2217/nnm-2020-0024. Epub 2020 Mar 12.

Abstract

Aim: To prepare pH-sensitive nanoparticle composed of alendronate (ALN) and poly(amidoamine) (PAMAM) to treat bone metastases of lung cancer. Methods: The solvent evaporation method was used to prepare docetaxel (DTX)-loaded ALN-PAMAM nanoparticles (DTX@ALN-PAMAM). Results: The in vitro results showed DTX@ALN-PAMAM significantly enhanced the anticancer activity of DTX and inhibited the formation of osteoclasts. DTX@ALN-PAMAM concentrated at bone metastasis site in mice, which resulted in the suppression of bone resorption, pain response and growth of bone metastases. Eventually, the therapeutic effect of DTX on bone metastases of lung cancer was obviously improved. Conclusion: ALN modified PAMAM nanoparticle could be an effective platform for the treatment of bone metastases of lung cancer.

Keywords: PAMAM; alendronate; bone metastasis; docetaxel; lung cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alendronate
  • Animals
  • Antineoplastic Agents* / therapeutic use
  • Bone Neoplasms* / drug therapy
  • Bone Neoplasms* / secondary
  • Docetaxel
  • Drug Delivery Systems
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / pathology
  • Mice
  • Nanoparticles*
  • Polyamines

Substances

  • Antineoplastic Agents
  • Poly(amidoamine)
  • Polyamines
  • Docetaxel
  • Alendronate