Crushed application of sofosbuvir and velpatasvir in a patient with swallowing disorder

Int J Antimicrob Agents. 2020 Jun;55(6):105934. doi: 10.1016/j.ijantimicag.2020.105934. Epub 2020 Mar 7.

Authors

Minou van Seyen¹, Anda D Samson², Lorraine Cullen³, Kirstine Eastick², Hanna Knol⁴, Angela Colbers⁴, David M Burger⁴

Affiliations

¹ Dept of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Minou.vanseyen@radboudumc.nl.
² Dept of Infection, Hull University Teaching Hospitals NHS trust, United Kingdom.
³ Dept of Pharmacy, Hull University Teaching Hospitals NHS trust, United Kingdom.
⁴ Dept of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.

PMID: 32156618
DOI: 10.1016/j.ijantimicag.2020.105934

No abstract available

Keywords: Crushing; Deglutition disorders; Hepatitis C; Pharmacokinetics; Sofosbuvir; Velpatasvir.

Publication types

Case Reports
Letter

MeSH terms

Antiviral Agents / administration & dosage*
Antiviral Agents / therapeutic use*
Carbamates / administration & dosage*
Carbamates / therapeutic use*
Deglutition Disorders / complications*
Drug Combinations
Hepatitis C, Chronic / drug therapy*
Heterocyclic Compounds, 4 or More Rings / administration & dosage*
Heterocyclic Compounds, 4 or More Rings / therapeutic use*
Humans
Male
Middle Aged
Sofosbuvir / administration & dosage*
Sofosbuvir / therapeutic use*
Stroke / complications

Substances

Antiviral Agents
Carbamates
Drug Combinations
Heterocyclic Compounds, 4 or More Rings
sofosbuvir-velpatasvir drug combination
Sofosbuvir