Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo

Yujia Peng; Yamei Yan; Peng Wan; Wei Dong; Kaiyin Huang; Linwu Ran; Jia Mi; Lu Lu; Xiaoxiong Zeng; Youlong Cao

doi:10.1016/j.foodres.2019.108952

Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo

Food Res Int. 2020 Apr:130:108952. doi: 10.1016/j.foodres.2019.108952. Epub 2019 Dec 26.

Authors

Yujia Peng¹, Yamei Yan², Peng Wan¹, Wei Dong¹, Kaiyin Huang¹, Linwu Ran³, Jia Mi², Lu Lu², Xiaoxiong Zeng⁴, Youlong Cao⁵

Affiliations

¹ College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China.
² National Wolfberry Engineering Research Center, Yinchuan 750002, Ningxia, China.
³ Laboratory Animal Center, Ningxia Medical University, Yinchuan 750004, Ningxia, China.
⁴ College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. Electronic address: zengxx@njau.edu.cn.
⁵ National Wolfberry Engineering Research Center, Yinchuan 750002, Ningxia, China. Electronic address: youlongck@126.com.

PMID: 32156393
DOI: 10.1016/j.foodres.2019.108952

Abstract

The relationship between diet, especially polyphenols, and health has been receiving increasing attention. Polyphenols were degraded by gut microbiota into metabolites and acted on the body to exert many bioactivities from several targets such as antioxidative stress, anti-inflammation, intestinal barrier and gut microbiota modulation. After long-term treatment of mice with anthocyanins from Lycium ruthenicum Murray (ACN), antioxidant status in liver (T-AOC, T-SOD, CAT, GSH and GSH-Px were increased and AST, ALT, ALP and MDA were decreased), anti-inflammatory status in colon (the expression of mRNA of iNos, Cox-2, Tnf-α, Il-6, Il-1β and Ifn-γ were significantly reduced), intestinal barrier (the expression of mRNA of Zo-1, Occludin, Claudin-1 and Muc1 were significantly increased) and gut microbiota (Barnesiella, Alistipes, Eisenbergiella, Coprobacter and Odoribacter were proliferated) were all regulated in ACN group. Meanwhile, the content of short-chain fatty acids in cecal contents and feces were increased. Taken together, long-term intake of ACN could promote organism healthy and these results have important implications for the development of ACN as a functional food ingredient.

Keywords: Anthocyanins; Gut microbiota; Lycium ruthenicum Murray; Organism health.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animal Feed
Animals
Anthocyanins / chemistry
Anthocyanins / pharmacology*
Diet / veterinary
Gastrointestinal Microbiome / drug effects*
Lycium / chemistry*
Male
Mice

Substances

Anthocyanins