VEGF Drives the Car toward Better Gas Exchange

Jaymin J Kathiriya; Harold A Chapman

doi:10.1016/j.devcel.2020.02.009

VEGF Drives the Car toward Better Gas Exchange

Dev Cell. 2020 Mar 9;52(5):546-547. doi: 10.1016/j.devcel.2020.02.009.

Authors

Jaymin J Kathiriya¹, Harold A Chapman²

Affiliations

¹ Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
² Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: hal.chapman@ucsf.edu.

Abstract

How lung epithelium and endothelium co-develop to maintain structural integrity of alveoli remains unclear. In this issue of Developmental Cell, Ellis et al. define how epithelial Vegfa directs development of a distinct endothelial cell population that ultimately plays a critical role in ensuring appropriate alveolar septation during alveologenesis.

Publication types

Comment

MeSH terms

Animals
Automobiles*
Endothelium
Lung
Mice
Pulmonary Alveoli
Vascular Endothelial Growth Factor A*

Substances

Vascular Endothelial Growth Factor A

Grants and funding

F32 HL143931/HL/NHLBI NIH HHS/United States