Don't Fence Me In: How Cancer Cells Divide in Crowded Spaces

Nawseen Tarannum; Sarah Woolner

doi:10.1016/j.devcel.2020.02.007

Don't Fence Me In: How Cancer Cells Divide in Crowded Spaces

Dev Cell. 2020 Mar 9;52(5):541-542. doi: 10.1016/j.devcel.2020.02.007.

Authors

Nawseen Tarannum¹, Sarah Woolner²

Affiliations

¹ Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine, & Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
² Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine, & Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address: sarah.woolner@manchester.ac.uk.

PMID: 32155433
DOI: 10.1016/j.devcel.2020.02.007

Abstract

Cells in our body have to divide within a defined tissue space, which in tumors is more restricted than in normal tissue. In this issue of Developmental Cell, Matthews et al. (2020) reveal that oncogenic Ras^V12-mediated cell rounding and cortical stiffening promote cell division under confined conditions that are similar to those in tumors.

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MeSH terms

Carcinogenesis*
Cell Division
Cell Shape
Humans
Neoplasms*
Signal Transduction