Abstract
The authors are reporting a case of autoimmune lymphoproliferative syndrome in a newborn who presented with massive hepatosplenomegaly, thrombocytopenia, and anemia at birth. Antenatal ultrasound revealed a fetus with hepatosplenomegaly. The infant was treated with steroids and sirolimus and is doing well at 4 years of age. This is the first case report of autoimmune lymphoproliferative syndrome presenting as hepatosplenomegaly during fetal life.
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
MeSH terms
-
Antibiotics, Antineoplastic / therapeutic use
-
Autoimmune Lymphoproliferative Syndrome / complications
-
Autoimmune Lymphoproliferative Syndrome / drug therapy
-
Autoimmune Lymphoproliferative Syndrome / pathology*
-
Female
-
Hepatomegaly / complications
-
Hepatomegaly / drug therapy
-
Hepatomegaly / pathology*
-
Humans
-
Infant, Newborn
-
Prognosis
-
Sirolimus / therapeutic use*
-
Splenomegaly / complications
-
Splenomegaly / drug therapy
-
Splenomegaly / pathology*
-
Thrombocytopenia / complications
-
Thrombocytopenia / drug therapy
-
Thrombocytopenia / pathology*
Substances
-
Antibiotics, Antineoplastic
-
Sirolimus