Shanghai international consensus on diagnosis and comprehensive treatment of colorectal liver metastases (version 2019)

Li Ren; Dexiang Zhu; Al B Benson 3rd; Bernard Nordlinger; Claus-Henning Koehne; Conor P Delaney; David Kerr; Heinz-Josef Lenz; Jia Fan; Jianping Wang; Jin Gu; Jin Li; Lin Shen; Petrv Tsarkov; Sabine Tejpar; Shu Zheng; Suzhan Zhang; Thomas Gruenberger; Xinyu Qin; Xishan Wang; Zhongtao Zhang; Graeme John Poston; Jianmin Xu; SINCE (Shanghai International Consensus Expert Group on Colorectal Liver Metastases) Group

doi:10.1016/j.ejso.2020.02.019

Shanghai international consensus on diagnosis and comprehensive treatment of colorectal liver metastases (version 2019)

Eur J Surg Oncol. 2020 Jun;46(6):955-966. doi: 10.1016/j.ejso.2020.02.019. Epub 2020 Feb 20.

Authors

Li Ren¹, Dexiang Zhu¹, Al B Benson 3rd², Bernard Nordlinger³, Claus-Henning Koehne⁴, Conor P Delaney⁵, David Kerr⁶, Heinz-Josef Lenz⁷, Jia Fan⁸, Jianping Wang⁹, Jin Gu¹⁰, Jin Li¹¹, Lin Shen¹², Petrv Tsarkov¹³, Sabine Tejpar¹⁴, Shu Zheng¹⁵, Suzhan Zhang¹⁶, Thomas Gruenberger¹⁷, Xinyu Qin¹, Xishan Wang¹⁸, Zhongtao Zhang¹⁹, Graeme John Poston²⁰, Jianmin Xu²¹; SINCE (Shanghai International Consensus Expert Group on Colorectal Liver Metastases) Group

Collaborators

SINCE (Shanghai International Consensus Expert Group on Colorectal Liver Metastases) Group:
Aiping Zhou, Amjad Parvaiz, Andrew Zhu, Cathy Eng, Chi-Wai Lau, Chun Song, Chung-Ngai Tang, Craig Lynch, Desen Wan, Evelyne Loyer, Federico Aucejo, Feng Wang, George J Chang, Gong Chen, Guang-Zhong Yang, Gyu-Seog Choi, Hulya Wieshmann, Inna Tulina, Jae Hwan Oh, James Cy Ngu, Jaw-Yuan Wang, Jian Zhou, Jing Jin, Jin-Tung Liang, Jiping Wang, Jung-Myun Kwak, Junji Okuda, Kang-Young Lee, Kefeng Ding, Li-Jen Kuo, Masaaki Ito, Masayuki Ohue, Mengsu Zeng, Michael Valente, Norikatsu Miyoshi, Paolo Pietro Bianchi, Ping Lan, Ruihua Xu, Sanjun Cai, Seon-Hahn Kim, Shan Wang, Shan Zeng, Simon Sm Ng, Smitha Krishnamurthi, Stephen Fenwick, Takashi Akiyoshi, Tianshu Liu, Tim Maughan, Tsuyoshi Konishi, Wai Lun Law, Wei Zhang, Weijing Sun, William Tzu-Liang Chen, Yajie Wang, Yi Wang, Ying Yuan, Yihong Sun, Yingyong Hou, YiQian Nancy You, Yoon-Suk Lee, Yunfeng Yao, Yunpeng Liu, Yusuke Kinugasa, Zhen Zhang, Zhiping Yan, Zhizhong Pan, Zhongfa Xu, Zongguang Zhou

Affiliations

¹ Department of Colorectal Surgery, Colorectal Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.
² Division of Hematology/Oncology, Northwestern Medical Group, Chicago, USA.
³ Surgery Department, Hospital Ambroise-Pare, Boulogne-Billancourt, France.
⁴ Department of Oncology and Haematology, Klinikum Oldenburg, Oldenburg, Germany.
⁵ Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
⁶ Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
⁷ Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁸ Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, China.
⁹ Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
¹⁰ Department of Colorectal Surgery, Peking University Cancer Hospital, Beijing, China; Department of Colorectal Surgery, Peking University Shougang Hospital, Beijing, China.
¹¹ Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
¹² Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital and Institute, Beijing, China.
¹³ Clinic of Colorectal and Minimally Invasive Surgery, Sechenov First Moscow State Medical University, Moscow, Russia.
¹⁴ Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium.
¹⁵ Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
¹⁶ Department of Surgical Oncology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
¹⁷ Department of Surgery, Rudolfstiftung Hospital, Vienna, Austria.
¹⁸ Department of Colorectal Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁹ Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, Beijing, China.
²⁰ Surgery Department, Aintree University Hospital, School of Translational Studies, University of Liverpool, Liverpool, UK. Electronic address: graemeposton@blueyonder.co.uk.
²¹ Department of Colorectal Surgery, Colorectal Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: xujmin@aliyun.com.

PMID: 32147426
DOI: 10.1016/j.ejso.2020.02.019

Abstract

The liver is the most common anatomical site for hematogenous metastases from colorectal cancer. Therefore effective treatment of liver metastases is one of the most challenging elements in the management of colorectal cancer. However, there is rare available clinical consensus or guideline only focusing on colorectal liver metastases. After six rounds of discussion by 195 clinical experts of the Shanghai International Consensus Expert Group on Colorectal Liver Metastases (SINCE) from 29 countries or regions, the Shanghai Consensus has been finally completed, based on current research and expert experience. The consensus emphasized the principle of multidisciplinary team, provided detailed diagnosis approaches, and guided precise local and systemic treatments. This Shanghai Consensus might be of great significance to standardized diagnosis and treatment of colorectal liver metastases all over the world.

Keywords: Colorectal liver metastases; Comprehensive therapy; Diagnosis; Multidisciplinary team.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

China / epidemiology
Colorectal Neoplasms / pathology*
Consensus*
Humans
Incidence
Liver Neoplasms / diagnosis
Liver Neoplasms / epidemiology
Liver Neoplasms / secondary*
Neoplasm Metastasis