Metformin along with other antidiabetic medications provide benefit to patients in the treatment of type 2 diabetes mellitus, but caution is advised in certain scenarios to avoid toxicity in kidney disease. Renal dosing, monitoring of kidney function, and evaluating the risk of developing serious side effects are warranted with some agents. The available literature with regard to incidence of adverse events and toxicity of hypoglycemic therapies is reviewed.
Keywords: Adverse effects; Chronic kidney disease; Diabetes mellitus; Safety; Toxicity.
Copyright © 2019 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.