[Modelling the bronchial epithelium in chronic obstructive pulmonary disease using human induced pluripotential stem cells]

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease leading to irreversible destruction of the terminal bronchioles. Although the precise patho-physiological mechanisms remain to be elucidated, the bronchial epithelium seems to play a pivotal role in the disease. Recent studies have highlighted a great heterogeneity among COPD patients, with various disease courses including, in about half the cases, an origin in childhood. Modelling of COPD is a major goal but currently available models are imperfect. Our work aims to create a new in vitro cellular model to study the pathology of the disease. The differentiation of human induced pluripotential stem cells (hiPSCs) in bronchial epithelium is a step towards a better understanding of the developmental origin and the identification of new therapeutic targets.

Keywords: Bronchial epithelium; Bronchopneumopathie chronique obstructive; Cellule souche pluripotente induite humaine; Chronic obstructive pulmonary disease; Différenciation dirigée; Directed differentiation; Human induced pluripotential stem cells; Épithélium bronchique.