Tackling the Many Facets of Glioblastoma Heterogeneity

Itay Tirosh; Mario L Suvà

doi:10.1016/j.stem.2020.02.005

Tackling the Many Facets of Glioblastoma Heterogeneity

Cell Stem Cell. 2020 Mar 5;26(3):303-304. doi: 10.1016/j.stem.2020.02.005.

Authors

Itay Tirosh¹, Mario L Suvà²

Affiliations

¹ Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address: itay.tirosh@weizmann.ac.il.
² Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: suva.mario@mgh.harvard.edu.

PMID: 32142659
DOI: 10.1016/j.stem.2020.02.005

Abstract

Glioblastoma is an incurable brain tumor notorious for its heterogeneity. Recent studies in Cell (Jacob et al., 2020) and Cell Stem Cell (Bhaduri et al., 2020) leverage novel glioblastoma organoid models and single-cell RNA-sequencing technologies to tackle glioblastoma's heterogeneous nature, providing new tools and insights into tumor biology.

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MeSH terms

Biological Specimen Banks*
Brain Neoplasms*
Glioblastoma*
Humans
Organoids
Sequence Analysis, RNA