Cancer-associated prothrombotic pathways: leucocytosis, but not thrombocytosis, correlates with venous thromboembolism in women with ovarian cancer

Intern Med J. 2020 Mar;50(3):366-370. doi: 10.1111/imj.14762.

Abstract

Risk factors for venous thromboembolism in cancer vary between tumours. Leucocytosis, thrombocytosis, tumour histology and vascular compression may drive thrombosis in ovarian cancer. Thrombosis developed in 13.4% of our patients. Higher median leucocyte, neutrophil and monocyte counts were related to thrombosis. Thrombocytosis >350 × 109 /L was frequent (63.8%), but not predictive of thrombosis. Identification of prothrombotic biomarkers may help personalise preventive treatments.

Keywords: cancer; leucocyte; ovarian; platelet; thrombosis.

MeSH terms

  • Carcinoma, Ovarian Epithelial
  • Female
  • Humans
  • Ovarian Neoplasms* / complications
  • Thrombocytosis* / diagnosis
  • Thrombosis*
  • Venous Thromboembolism* / diagnosis
  • Venous Thromboembolism* / epidemiology
  • Venous Thromboembolism* / etiology