Anaplastic carcinoma of the thyroid with sclerohyaline nodules

Runjan Chetty; Alan E Mills; Virginia A LiVolsi

doi:10.1007/BF02914461

Anaplastic carcinoma of the thyroid with sclerohyaline nodules

Endocr Pathol. 1993 Jun;4(2):110-114. doi: 10.1007/BF02914461.

Authors

Runjan Chetty¹, Alan E Mills², Virginia A LiVolsi³

Affiliations

¹ Department of Anatomical Pathology, The Royal Melbourne Hospital, Melbourne.
² Dorevitch Pathology, Bendigo, Australia.
³ Department of Pathology and Laboratory Medicine, Surgical Pathology Section, University of Pennsylvania Medical Center, Philadelphia.

PMID: 32138415
DOI: 10.1007/BF02914461

Abstract

Sclerohyaline nodules, resembling deposits of amyloid, were noted in 3 cases of anaplastic thyroid carcinoma (ATC). All 3 patients were elderly, and 2 had good outcomes. Histologically, the nodules were dispersed throughout typical areas of ATC and formed the dominant histologic feature in these areas. The nodules were paucicellular and surrounded by both ATC and chronic inflammatory cells, including prominent numbers of eosinophils. Other areas of the stroma had a more keloidal appearance with minor myxoid foci. The hyaline nodules were negative for calcitonin, amyloid A, type IV collagen, and laminin. We regard these nodules as a response of the extracellular matrix to infiltrating ATC.

Keywords: Anaplastic Thyroid Carcinoma; Endocrine Pathology Volume; Mucoepidermoid Carcinoma; Papillary Thyroid Carcinoma; Spindle Cell.