Patients with uremia can suffer from decreased renal function and endocrine and metabolism disorders,which can lead to the accumulation of toxins in the body.Accumulation of uremic toxins is a major cause of cognitive dysfunction in uremic patients.This article summarizes some of the cognitive dysfunction-related uremic toxins and their possible mechanisms.
尿毒症时患者由于肾功能水平明显下降,内分泌及代谢功能发生紊乱,导致体内毒素蓄积而产生毒性作用。尿毒症毒素蓄积是尿毒症患者认知功能障碍的重要原因,本文总结了近年来发现的与尿毒症认知功能障碍发生有关的一些尿毒症毒素及其可能的作用机制。.
Keywords: cognitive impairment; inflammation; uremic toxin.