[Application of Single-cell RNA Sequencing in Research on Tumor Immune Microenvironment]

Kai Li Yang; Zhao Sun; Chun Mei Bai; Lin Zhao

doi:10.3881/j.issn.1000-503X.11194

[Application of Single-cell RNA Sequencing in Research on Tumor Immune Microenvironment]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Feb 28;42(1):117-123. doi: 10.3881/j.issn.1000-503X.11194.

[Article in Chinese]

Authors

Kai Li Yang¹, Zhao Sun¹, Chun Mei Bai¹, Lin Zhao¹

Affiliation

¹ Department of Medical Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100032,China.

PMID: 32131950
DOI: 10.3881/j.issn.1000-503X.11194

Abstract

Tumors are highly complex systems. Understanding the compositions and functions of the tumor immune microenvironment is a prerequisite for effective tumor immunotherapy. Single-cell RNA sequencing can detect the transcriptome of a cell at the resolution of single-cell level,describe its functional status,and thus deepen the understanding of the composition and function of different cell clusters in tumor immune microenvironment. This article reviews the application of single-cell RNA sequencing in research on tumor immune microenvironment.

Keywords: cell cluster; immunosuppression; single-cell RNA sequencing; tumor heterogeneity; tumor immune microenvironment.

Publication types

Review

MeSH terms

Humans
Immunotherapy
Neoplasms / genetics*
Neoplasms / immunology*
Sequence Analysis, RNA*
Single-Cell Analysis*
Transcriptome
Tumor Microenvironment*