Appetite for Arginine: Metabolic Control of Macrophage Hunger

Daniel J Puleston; Erika L Pearce

doi:10.1016/j.cmet.2020.02.005

Appetite for Arginine: Metabolic Control of Macrophage Hunger

Cell Metab. 2020 Mar 3;31(3):441-442. doi: 10.1016/j.cmet.2020.02.005.

Authors

Daniel J Puleston¹, Erika L Pearce²

Affiliations

¹ Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; The Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
² Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: pearce@ie-freiburg.mpg.de.

PMID: 32130876
DOI: 10.1016/j.cmet.2020.02.005

Abstract

Engulfment of dying cells by phagocytes is essential to maintain tissue function and promote injury resolution and repair. This process, termed efferocytosis, requires persistent corpse engulfment and remains a poorly understood mechanism. Here, we preview findings from Yurdagul et al. (2020) that detail how continual efferocytosis is supported by metabolites derived from the dying cell itself.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Apoptosis
Appetite*
Arginine
Hunger*
Macrophages
Phagocytosis

Substances

Arginine

Grants and funding

WT_/Wellcome Trust/United Kingdom