Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation

Céline A Schoonjans; Bernard Gallez

doi:10.1007/978-3-030-34025-4_6

Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation

Adv Exp Med Biol. 2020:1219:109-123. doi: 10.1007/978-3-030-34025-4_6.

Authors

Céline A Schoonjans¹, Bernard Gallez²

Affiliations

¹ Université catholique de Louvain (UCLouvain), Louvain Drug Research Institute, Brussels, Belgium.
² Biomedical Magnetic Resonance, Brussels, Belgium. bernard.gallez@uclouvain.be.

PMID: 32130696
DOI: 10.1007/978-3-030-34025-4_6

Abstract

Dysregulated metabolism is a key hallmark of cancer cells and an enticing target for cancer treatment. Since the last 10 years, research on cancer metabolism has moved from pathway attention to network consideration. This metabolic complexity continuously adapt to new constraints in the tumor microenvironment. In this review, we will highlight striking changes in cancer cell metabolism compared to normal cells. Understanding this tumor metabolic plasticity suggests potential new targets and innovative combinatorial treatments for fighting cancer.

Keywords: Acidosis; Amino acid; Bioenergetics; Combined therapies; Fatty acid; Glycolysis; Hypoxia; Metabolic reprogramming; Mitochondria.

Publication types

Review

MeSH terms

Humans
Neoplasms / drug therapy
Neoplasms / metabolism*
Nutrients / metabolism*
Tumor Microenvironment