Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms

Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02073-19. doi: 10.1128/AAC.02073-19. Print 2020 Apr 21.

Abstract

Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

Keywords: HT61; Staphylococcus aureus; antibiotics; biofilms; proteomics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects*
  • Biofilms / growth & development
  • Humans
  • Microbial Sensitivity Tests
  • Quinolines / pharmacology*
  • Staphylococcal Infections / drug therapy
  • Staphylococcus aureus / drug effects*
  • Vancomycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • HT61 compound
  • Quinolines
  • Vancomycin