Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Further development of sepsis usually leads to septic shock or even death. Many previous studies have focused on the abnormal reactions of monocytes/macrophages, neutrophils, complement system, or cytokine inflammation in sepsis. Many evidences in recent years suggest that dendritic cells, as the most powerful antigen-presenting cells in innate immune system of body, play important role during the process of immune disorders of sepsis. In this article, I review the main classification, immune function, monitoring method, regulatory pathways of dendritic cells and their clinical significance in immune disorders of sepsis, so as to find new strategies for immune regulation of sepsis.
脓毒症是机体对感染反应失调所致危及生命的器官功能障碍，进一步发展则常导致脓毒症休克甚至死亡。既往许多研究关注脓毒症状态下单核/巨噬细胞、中性粒细胞、补体系统、细胞因子炎症反应等异常改变。近年来的资料提示，树突状细胞作为机体天然免疫系统最为强大的抗原提呈细胞，在脓毒症免疫紊乱过程中发挥重要作用。本文中，笔者通过对树突状细胞主要分类、免疫功能、监测方法、调控途径及其在脓毒症免疫障碍中的临床意义进行综述，旨在为脓毒症免疫调节寻求新的策略。.
Keywords: Dendritic cells; Immunity; Sepsis.