Prognostic Values of LDH and CRP in Cervical Cancer

Han Wang; Meng-Sen Wang; Yong-Heng Zhou; Jian-Ping Shi; Wen-Jie Wang

doi:10.2147/OTT.S235027

Prognostic Values of LDH and CRP in Cervical Cancer

Onco Targets Ther. 2020 Feb 11:13:1255-1263. doi: 10.2147/OTT.S235027. eCollection 2020.

Authors

Han Wang^#¹, Meng-Sen Wang^#², Yong-Heng Zhou^#¹, Jian-Ping Shi³, Wen-Jie Wang³

Affiliations

¹ Department of Oncology, Jining Cancer Hospital, Jining, Shandong, People's Republic of China.
² Department of Oncology, Jining No. 1 People's Hospital, Jining, Shandong, People's Republic of China.
³ Department of Radio-Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.

Patients and methods: Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan-Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.

Results: High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.

Conclusion: LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer.

Keywords: CRP; LDH; OS; cervical cancer; prognosis.

Grants and funding

This study was supported by the Science and Education for Health Foundation of Suzhou for Youth (grant no. KJXW2018030 and KJXW2018032), the Science and Technology Project Foundation of Suzhou (grant no. SS201651), the Education Research Project Foundation of Nanjing Medical University (grant no. FZS-ZD-201701), Project of Clinical Expert Team Introduction in Suzhou (SZYJTD201807), Project of science and technology development plan in Suzhou (SYSD2018138), and the Jiangsu Province Medical key discipline (grant no. ZDXKC2016007).