Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system

Tingting Peng; Yin Shi; Chune Zhu; Disang Feng; Xiangyu Ma; Peipei Yang; Xuequn Bai; Xin Pan; Chuan-Yu Wu; Wen Tan; Chuanbin Wu

doi:10.1016/j.dib.2020.105269

Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system

Data Brief. 2020 Feb 8:29:105269. doi: 10.1016/j.dib.2020.105269. eCollection 2020 Apr.

Authors

Tingting Peng¹, Yin Shi¹, Chune Zhu², Disang Feng¹, Xiangyu Ma³, Peipei Yang¹, Xuequn Bai¹, Xin Pan¹, Chuan-Yu Wu⁴, Wen Tan², Chuanbin Wu¹

Affiliations

¹ School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
² Institute for Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.
³ College of Pharmacy, University of Texas at Austin, Austin, 78712, USA.
⁴ Department of Chemical and Process Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.

Abstract

Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs greatly contributed to facilitating drug release, which was detailed in a research article entitled "Huperzine A loaded multiparticulate disintegrating tablet: Drug release mechanism of ethyl cellulose microparticles and pharmacokinetic study" (Peng et al., 2019) [1]. In this article, the influence of different polymers and drugs on the drug release behavior was investigated to broaden or compensate this finding. Besides, powder characterization of MPs was used to evaluate the further application of MPs for tablets.

Keywords: Drug release profile; Microparticles; Powder characteristic.