Pharmacometric models simulation using NONMEM, Berkeley Madonna and R

Abstract

In this tutorial, we introduce a differential equation simulation model for use in pharmacometrics involving NONMEM, Berkeley Madonna, and R. We report components of the simulation code and similarities/differences between software, rather than how to use each software. Depending on the purpose of the simulation, an appropriate tool can be selected for effective communication.

Keywords: Berkeley Madonna; NONMEM; Pharmacometrics; R; Simulation.