Mobilization and Collection of HSC

Kai Hübel

doi:10.1007/978-3-030-02278-5_15

Mobilization and Collection of HSC

Review

In: The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]. 7th edition. Cham (CH): Springer; 2019. Chapter 15.

Author

Kai Hübel¹

Book Editors

Enric Carreras¹, Carlo Dufour², Mohamad Mohty³, Nicolaus Kröger⁴

Affiliation

¹ University of Cologne, Department of Internal Medicine, Cologne, Germany

Book Affiliations

¹ Spanish Bone Marrow Donor Registry, Josep Carreras Foundation and Leukemia Research Institute, Catalunya, Barcelona, Spain
² Hematology Unit, IRCCS Giannina Gaslini, Geneva, Switzerland
³ Department of Hematology, Pierre and Marie Curie University, Paris, France
⁴ Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppend, Hamburg, Germany

Excerpt

The intravenous infusion of patient’s own HSC to restore BM damage is the basic principle of high-dose chemotherapy, since otherwise the patient would expect long-lasting aplasia with life-threatening infections. Therefore, a sufficient collection of HSC before application of high-dose therapy is mandatory. Since HSC expresses CD34 on their surface, the number of CD34+ cells in the transplant material is considered as an indicator of the HSC content.

Sections

Publication types

Review