Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar

J Glob Antimicrob Resist. 2020 Sep:22:122-125. doi: 10.1016/j.jgar.2020.02.011. Epub 2020 Feb 19.

Abstract

Objective: The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar.

Methods: A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified.

Results: Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored blaNDM-1, and 28 did armA or armA2 CONCLUSIONS: A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.

Keywords: 16S rRNA methylase; Multidrug-resistant Acinetobacter baumannii; molecular epidemiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter baumannii* / genetics
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Drug Resistance, Multiple, Bacterial / genetics
  • Hospitals
  • Microbial Sensitivity Tests
  • Molecular Epidemiology
  • Myanmar / epidemiology
  • Phylogeny
  • RNA, Ribosomal, 16S
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • RNA, Ribosomal, 16S
  • beta-Lactamases