SIRT1 and aging related signaling pathways

Cui Chen; Min Zhou; Yuchen Ge; Xiaobo Wang

doi:10.1016/j.mad.2020.111215

SIRT1 and aging related signaling pathways

Mech Ageing Dev. 2020 Apr:187:111215. doi: 10.1016/j.mad.2020.111215. Epub 2020 Feb 19.

Authors

Cui Chen¹, Min Zhou¹, Yuchen Ge¹, Xiaobo Wang²

Affiliations

¹ School of Basic Medicine, Dali University, Dali, Yunnan, 671000, China.
² School of Basic Medicine, Dali University, Dali, Yunnan, 671000, China; Key Laboratory of University Cell Biology Yunnan Province, Dali, Yunnan, 671000, China. Electronic address: wxb4320062@163.com.

PMID: 32084459
DOI: 10.1016/j.mad.2020.111215

Abstract

Aging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD⁺-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend lifespan in yeast, caenorhabditis elegans and mice. In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will be discussed. Meanwhile, the potential therapeutic strategies of targeting SIRT1 to anti-aging are also addressed.

Keywords: Aging; Deacetylate; NAD(+); SIRT1; Signaling pathways.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / genetics
Aging / metabolism*
Animals
Humans
Mice
Signal Transduction*
Sirtuin 1 / genetics
Sirtuin 1 / metabolism*

Substances

SIRT1 protein, human
Sirt1 protein, mouse
Sirtuin 1